Endocrine Abstracts

Introduction: Schwannomas are tumors derived from myelin sheat of nerves which can displace and compress nerves causing pain, weakness and numbness. Very rarely they become malignant.Case report: Thirty-one years old patient was hospitalized at our Department to evaluate hypopituitarism. He was born at term by cesarean section, with hydrocephalus and did not start to breath spontaneously. A few months later, he was diagnosed with scoliosis thoracalis dup...

AI are incidentally discovered adrenal masses without any prior suspicions of adrenal disease. They are most frequently hormonally inactive, with arterial hypertension (AH) as a common finding.The aim was to determine upright and supine PR and ALD levels in patients with AI, normotensive and hypertensive.Two hundred and eight patients (148 women and 60 men, mean age 55.08±11.02 years, mean BMI 27.91±4.6 kg/m2) ...

Many studies have shown insulin resistance (IR) in majority of patients with adrenal incidentaloma. The euglycaemic hyperinsulinaemic glucose clamp technique is still considered as ‘golden standard’ for evaluation of insuline sensitivity. These methods are also complicated, labor-intensive procedure better for small research studies. Today, several surrogate indexes for insulin sensitivity were introduced such as: HOMA, QUIQI or G/IR. Some studies showed that QUIQI h...

Subclinical hyperthyroidism is a biochemical diagnosis defined with suppressed levels of TSH and normal levels of thyroid hormones. One of the main metabolic responses to thyroid hyperfunction is peripheral lipolysis and release of free fatty acids (FFA). The aim of this study was to compare levels of cholesterol, LDL, HDL and triglycerides in persons with subclinical hyperthyroidism to age and BMI matched euthyroid healthy control. We evaluated 45 persons in two groups: 1st g...

Subclinical hypothyroidism is a biochemical diagnosis defined with elevated levels of TSH and normal levels of thyroid hormones. The most common abnormality linked to this condition is hypercholesterolemia. The aim of this study was to search for MSy among the persons with subclinical hypothyroidism which was already proven to have hypercholesterolemia when compared to healthy control. MSy was identified in those with elevated triglycerides (Tgc), reduced HDL and elevated fast...

Several studies show that characteristics of metabolic syndrome are often seen in patients with adrenal incidentaloma. The aim of our study was to evaluate metabolic factors in these patients. 208 patients (148 female and 60 male, age 55.08±11.02 y’s and BMI 27.91±4.6 kg/m2) were admitted and biochemical, endocrine testing were performed. Lipid status: cholesterol 5.77±1.26 mmol/L, triglyceride 1.92±0.98 mmol/L. 113(55%) patients were hypert...

POF is a disease of unclear origin affecting women under age 40. They are at high risk of cardiovascular diseases (CVD).The objective of this study was to compare the lipid status and atherogenic indexes - total cholesterol/high density lipoprotein (TC/HDL) and low density lipoprotein/HDL (LDL/HDL) - of women with POF with healthy women of the same age and the same BMI.We evaluated 54 women in two groups. 1st group: 31 women with P...

Introduction: The most common cause for persistent elevation of TSH levels in hypothyroid patients treated with levothyroxine is poor compliance. The levothyroxine absorption test (LAT) is usually confirmed this phenomenon called “pseudo-malabsorption”.Case report: Sixty-year-old female, weight 60 kg, BMI 24.3 kg/m2, presented with sleepiness, tiredness, fatigue and forgetfulness. Her skin was very dry and flaky. She had low toleranc...

Pseudohypoparathyroidism type 1a (PHP1a) is disorder characterised by resistance to the biological actions of circulating parathyroid hormone (PTH) along with typical features of Albright’s hereditary osteodystrophy (AHO). Tissue-specific imprinting of GNAS gene results in complete resistance to PTH in renal proximale tubule, but skeletal responsiveness to PTH appears intact, since Gαs is biallelically expressed in human bones. The objective of this study was to dete...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...